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L-685 458
L-685 458
$87 - $2600
Product name
L-685 458
Cas No
292632-98-5
MF
C39H52N4O6
MW
672.85
MDL Number
MFCD03093402
Synonyms
(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide;N-[(2R,4R,5S)-5-[[(1,1-DiMethylethoxy)carbonyl]aMino]-4-hydroxy-1-oxo-6- phenyl-2-(phenylMethyl)hexyl]-L-leucyl-L-phenylalaninaMide;CS-2367;L-685458 (L-685,458;L-685458;L 685458;L685458;L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-;Apoptosis,alzheimer’s disease,L 685458,inhibit,L685458,HES1,cancer,Inhibitor,Gamma secretase,γ-secretase,L-685458;L-685,458, gamma-secretase inhibitor
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Price
59 prices
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aablocks
Cayman Chemical
ApexBio Technology
Arctom
Biosynth
ChemScene
AK Scientific
TRC
ACHEMBLOCK
DC Chemicals
Ambeed
Sigma-Aldrich
Crysdot
Chem-Impex
Usbiological
American Custom Chemicals Corporation
CSNpharm
Medical Isotopes, Inc.
Package
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10mm*1mlindmso(solution)
0.025mg
0.05mg
10mm*1mlindmso(solid+solvent)
0.1mg
10mm(1mlindmso)
250ug
0.25mg
0.5mg
500ug
1mg
2mg
5mg
10mg
25mg
50mg
100mg
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Brand
Packaging
Price
Product name
aablocks
AA002XTK
1mg
$87
L-685458
aablocks
AA002XTK
5mg
$249
L-685458
aablocks
AA002XTK
10mg
$407
L-685458
aablocks
AA002XTK
25mg
$767
L-685458
aablocks
AA002XTK
50mg
$1036
L-685458
aablocks
AA002XTK
100mg
$1372
L-685458
ACHEMBLOCK
U102942
25MG
$1120
L-685458
ACHEMBLOCK
U102942
100MG
$2025
L-685458
ACHEMBLOCK
U102942
5MG
$445
L-685458
AK Scientific
1682CP
10mg
$232
l-685,458
1
of
6
Properties
Melting point
212-213 °C
Boiling point
938.5±65.0 °C(Predicted)
Density
1.155±0.06 g/cm3(Predicted)
storage temp.
-20°C
solubility
DMSO: >10 mg/mL, soluble
form
solid
pka
12.09±0.46(Predicted)
color
white
InChIKey
MURCDOXDAHPNRQ-ZJKZPDEISA-N
SMILES
C(N)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1
Description
L-685,458 is a potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. It exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides.
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tert-butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanyl-OH
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Z-ILE-PHE-OH
$128.33-1355
Suppliers and manufacturers
TargetMol Chemicals Inc.
$122.00
L-685458
CAS:292632-98-5
Shaanxi Dideu New Materials Co. Ltd
L-685 458
CAS:292632-98-5
BOC Sciences
TargetMol Chemicals Inc.
Aladdin Scientific
NANJING YINGWEN BIOTECHNOLOGY CO LTD
Shanghai fuxiang biotechnology co., ltd
J & K SCIENTIFIC LTD.
Chembest Research Laboratories Limited
Shanghai Hanhong Scientific Co.,Ltd.
More related product prices
tert-butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanyl-OH
Z-ILE-PHE-OH
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