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L-685 458
L-685 458
$152.5 - $2600
Product name
L-685 458
Cas No
292632-98-5
MF
C39H52N4O6
MW
672.85
MDL Number
MFCD03093402
Synonyms
(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide;N-[(2R,4R,5S)-5-[[(1,1-DiMethylethoxy)carbonyl]aMino]-4-hydroxy-1-oxo-6- phenyl-2-(phenylMethyl)hexyl]-L-leucyl-L-phenylalaninaMide;CS-2367;L-685458 (L-685,458;L-685458;L 685458;L685458;L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-;Apoptosis,alzheimer’s disease,L 685458,inhibit,L685458,HES1,cancer,Inhibitor,Gamma secretase,γ-secretase,L-685458
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Price
24 prices
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Sigma-Aldrich
Cayman Chemical
CSNpharm
Crysdot
TRC
ApexBio Technology
AK Scientific
Medical Isotopes, Inc.
ChemScene
American Custom Chemicals Corporation
Biosynth Carbosynth
Ambeed
DC Chemicals
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500ug
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2mg
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Brand
Packaging
Price
Product name
AK Scientific
1682CP
10mg
$232
l-685,458
Ambeed
A142296
5mg
$552
L-685458
Ambeed
A142296
10mg
$1066
L-685458
American Custom Chemicals Corporation
INB0000845
1MG
$774.95
L-685,458
ApexBio Technology
A4404
5mg
$450
L-685,458
Biosynth Carbosynth
FT109461
1mg
$459
L-685458
Biosynth Carbosynth
FT109461
500ug
$265
L-685458
Biosynth Carbosynth
FT109461
250ug
$152.5
L-685458
Biosynth Carbosynth
FT109461
2mg
$799
L-685458
Biosynth Carbosynth
FT109461
5mg
$1736.95
L-685458
1
of
3
Properties
Melting point
212-213 °C
Boiling point
938.5±65.0 °C(Predicted)
Density
1.155±0.06 g/cm3(Predicted)
storage temp.
-20°C
solubility
DMSO: >10 mg/mL, soluble
form
solid
pka
12.09±0.46(Predicted)
color
white
Description
L-685,458 is a potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. It exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides.
Suppliers and manufacturers
TargetMol Chemicals Inc.
$122.00
/1mg
L-685458
CAS:292632-98-5
Alpha Biopharmaceuticals Co., Ltd
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Nextpeptide Inc
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
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