ABHD16A (also known as HLA-B associated transcript 5 (BAT5)) is a phosphatidylserine hydrolase that regulates the formation of lysophosphatidylserines (lyso-PSs) and has been implicated in certain immunological and neurological diseases. KC01 is a covalent inhibitor of ABHD16A (IC50s = 90 and 520 nM for human and mouse, respectively). It has been shown to deplete lyso-PS from various human cancer cell lines, a lymphoblast cell line, and mouse brain membrane lysates and to decrease LPS-induced cytokine production in macrophages. This compound has been used to characterize the role of ABHD16A as a principle phosphatidylserine lipase in vivo.
