IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.
1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC
50 = 0.54 ng/ml).
1 IKD-8344 inhibits growth of the mycelial form of
C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium
B. cenocepacia.
2,3 It is active against
T. spiralis in vitro and
in vivo.
1
