GW 590735 is an activator of peroxisome proliferator-activated receptors (PPARs) α, β and γ, which are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARα results in increased clearance of triglyceride (TG) rich very low-density lipoprotein. GW 590735 is a selective and potent agonist of PPARα with an EC50 value of 4 nM.