BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO . It potently inhibits GSK3α/β (IC50 = 10 nM), with selectivity over Cdk5/p25, Cdk2/A, and Cdk1/B (IC50s = 2.4, 4.3, and 63 μM, respectively). BIO-Acetoxime has been used to study the role of GSK3 in the Wnt/β-catenin pathway. It also suppresses the cytopathic effects of herpes viruses and reduces viral yields in human oral epithelial cells.
