Glycerophospho-N-palmitoyl ethanolamine (GP-NPEA) is the metabolic precursor of palmitoyl ethanolamide (PEA). PEA is an endogenous cannabinoid found in liver, brain, and other mammalian tissues, that has potent antiinflammatory activity. PEA has no appreciable affinity for CB1 and low affinity for CB2, suggesting that its efficacy is through a different receptor.
