Fosaprepitant dimeglumine

$5 - $80099

Product nameFosaprepitant dimeglumine
Cas No265121-04-8
MFC30H39F7N5O11P
MW809.63
EINECS682-419-4
MDL NumberMFCD23102059

Synonyms

Phosphonic acid, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:2);Unii-D35fm8T64x;[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate 1-Deoxy-1-(MethylaMino)-D-glucitol;1-Deoxy-1-(MethylaMino)-D-glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate;1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL [[(2R,3S]-2-[(1R)-1-[3,5-BIS (TRIFLUOROMETHYL)PHENYL] PHENYL]ETHOXY]-(4-FLUOROPHENYL);3-[2(R)-[1(R)-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)Morpholin-4-ylMethyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-phosphinic acid bis(N-Methyl-D-glucaMine) salt;Fosaprepitant dimeglumine, >=99%;Fosaprepitant dimegluminer

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Arctom Ambeed aablocks AK Scientific CSNpharm AvaChem ChemScene Cayman Chemical ApexBio Technology Biosynth Sigma-Aldrich TCI Chemical DC Chemicals ACHEMBLOCK TRC Usbiological Crysdot Chemenu Biorbyt Ltd Medical Isotopes, Inc. Chemtos
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1mg 5mg 10mg 25mg 50mg 100mg 250mg 500mg 1000mg 10mm*1mlindmso 1g 2g 2000mg 5g 10g 10mm(in1mldmso)

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Brand	Packaging	Price	Product name
aablocks AA00BF0O	5mg	$10	Fosaprepitant dimeglumine
aablocks AA00BF0O	50mg	$21	Fosaprepitant dimeglumine
aablocks AA00BF0O	100mg	$29	Fosaprepitant dimeglumine
aablocks AA00BF0O	250mg	$44	Fosaprepitant dimeglumine
aablocks AA00BF0O	1g	$121	Fosaprepitant dimeglumine
ACHEMBLOCK Z238363	1G	$150	Fosaprepitant dimeglumine
ACHEMBLOCK Z238363	5G	$525	Fosaprepitant dimeglumine
AK Scientific X3475	10g	$720	Fosaprepitant dimeglumine
AK Scientific X3475	1g	$125	Fosaprepitant dimeglumine
AK Scientific J11396	10mg	$226	Fosaprepitantdimeglumine

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Properties

storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	≥50.24 mg/mL in DMSO; insoluble in EtOH; ≥13.16 mg/mL in H2O with ultrasonic
form	Powder
pka	Fosaprepitant dimeglumine has four functional groups which have pKa values of 3.05 ± 0.03, 4.92 ± 0.02, 9.67 ± 0.01 and 10.59 ± 0.03. The pka value of 3.05 corresponds to the morpholinium group, the pka of 4.92 corresponds to the monophosphonate group, the pka of 9.67 corresponds to the meglumine counter ion, and the pka of 10.59 corresponds to the triazolinone NH group.
color	White to off-white
optical activity	[α]/D +27 to +34°, c =0.5 in methanol
Water Solubility	H2O: 2mg/mL, clear
InChIKey	UGJUJYSRBQWCEK-QBRZKSSTNA-N
SMILES	FC1=CC=C([C@@H]2N(CCO[C@@H]2O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)CC(NC4=O)=NN4P(O)(O)=O)C=C1.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

Fosaprepitant dimeglumine is a water-soluble prodrug form of the neurokinin-1 receptor antagonist aprepitant. Formulations containing fosaprepitant dimeglumine have been used to prevent chemotherapy-induced nausea and vomiting.

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