FD 211

FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.¹ It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC₅₀s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC₅₀ = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC₅₀ = 1.25 μg/ml for all).