The lysophosphatidic acid (LPA) receptor LPA2 is a G protein-coupled receptor that has roles in protecting against radiation-induced cell death. DBIBB is a non-lipid agonist of LPA2 (EC50 = 0.10 μM) that is without effect at other LPA receptor subtypes. It protects rat intestinal crypt epithelium-like IEC-6 cells against caspase 3/7 activation and apoptosis following irradiation. DBIBB dose-dependently attenuates radiation-induced DNA damage in mouse embryo fibroblasts (MEFs) expressing LPA2 but not in MEFs lacking this receptor. It also increases the survival of mice suffering from hematopoietic acute radiation syndrome after total-body irradiation.
