CRANAD 28

$32 - $1268

Product nameCRANAD 28
Cas No1623747-97-6
MFC27H23BF2N4O2
MW484.3049264
MDL NumberMFCD30719248

Synonyms

CRANAD 28;4-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole;1,7-Bis(5-methyl-1-phenyl-1H-pyrazol-4-yl)hepta-1,6-diene-3,5-dione-difluoroboron;4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole);CRANAD-28,beta plaques,Inhibitor,CRANAD 28,inhibit;4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole)

show less show more

Price

5 prices

Brand less more

Cayman Chemical AK Scientific
Package less more

500μg 1mg 5mg 10mg 50mg

Clear All Done

Brand	Packaging	Price	Product name
AK Scientific SYN5491	50mg	$1268	CRANAD-28
Cayman Chemical 19816	500μg	$32	CRANAD 28
Cayman Chemical 19816	1mg	$61	CRANAD 28
Cayman Chemical 19816	5mg	$243	CRANAD 28
Cayman Chemical 19816	10mg	$426	CRANAD 28

Properties

storage temp.	Store at -20°C
solubility	DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form	A crystalline solid
color	Orange to red

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321：Specific treatment (see … on this label).

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (K_ds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.

Suppliers and manufacturers

TargetMol Chemicals Inc.

$54.00/1mg

CRANAD-28

CAS:1623747-97-6
Career Henan Chemica Co
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Wuhan Jingkang en Biomedical Technology Co., Ltd
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Shanghai Lollane Biological Technology Co.,Ltd.
Nanjing XiZe Biotechnology CO., Ltd.
Shanghai EFE Biological Technology Co., Ltd.

Send Inquriy