FFAR4 (GPR120) (C-Term) Polyclonal Antibody

G Protein-Coupled Receptor (GPR120) is a GPCR activated by the presence of long chain free fatty acids and is expressed in adipocytes and pro-inflammatory macrophages. The activation of GPR120 results in elevated Ca²⁺ and activation of the ERK cascade. ω-3 Fatty acid constituents such as DHA and EPA mediate GPR120 signaling resulting in inhibition of TLR and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner. The anti-inflammatory effects of GPR120 are indirectly involved in promoting insulin secretion and free fatty acid-induced inhibition of apoptosis. The predicted size for GPR120 is 42.2 kDa and the observed detection is approximately 43 kDa by Western blot.