Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) (Item No. 24889).1 It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II (Item No. 17150) and endothelin-1 (Item No. 24127) from isolated rat aorta. In vivo, adrenomedullin (13-52) decreases mean arterial pressure (MAP) in spontaneously and renal hypertensive rats in a dose-dependent manner. Adrenomedullin (13-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 (Item No. 16450) in a dose-dependent manner in cats but has no effect on basal lobar arterial pressure or systemic arterial pressure.2 It also potentiates inflammatory edema and neutrophil accumulation in rats.3WARNING This product is not for human or veterinary use.
