Membrane-bound O-acyltransferase 2 (MBOAT2) is a membrane-spanning enzyme of the MBOAT family encoded by the LPCAT4 gene in humans.1 It contains multiple transmembrane domains and has two active site residues, an asparagine and a histidine, in common with other MBOAT family members.1 MBOAT2 is expressed in mouse epididymis, brain, testis, and ovary and is localized to the endoplasmic reticulum in CHO cells.2 MBOAT2 has acyltransferase activities, with a preference for using oleoyl-coenzyme A (oleoyl-CoA) as an acyl donor and lysophosphatidylethanolamine (Item No. 25844), lysophosphatidic acid, or lysophosphatidylcholine (Item No. 24331) as acyl acceptors at the sn-2 position.3 MBOAT2 expression is increased in the epithelia of patient-derived pancreatic ductal adenocarcinoma (PDAC) tumor tissue and this expression is inversely correlated with patient survival.4 In contrast, decreased expression of serum circular MBOAT2 RNA levels are found in patients with hypertrophic cardiomyopathy.5 Cayman’s MBOAT2 (Internal) Polyclonal Antibody can be used for flow cytometry and immunofluorescence applications. The antibody recognizes the internal (cytoplasmic) portion of MBOAT2.WARNING This product is not for human or veterinary use.
