Prostaglandin D2 (PGD2) elicits its biological function through interaction with two distinct G protein-coupled receptors, DP1 and CRTH2/DP2. CRTH2 primarily couples to Gi or Gq subunits to mobilize Ca2+, induce cell migration, and up-regulate adhesion molecules.1 CRTH2 mRNA has been detected in various tissues including liver, lung, kidney, brain, heart, thymus, and spleen and in various cell lineages including both hematopoietic and non-hematopoietic cell lines.2 Human CRTH2 is 395 amino acids in length with an estimated molecular weight of 43 kDa. Cayman’s CRTH2/DP2 receptor (N-Term) polyclonal antibody can be used for western blot and immunohistochemical analysis of CRTH2 on samples of human, bovine, murine, and rat origin. It detects both unglycosylated and glycosylated protein at sizes ranging from 35-40 kDa to 50-70 kDa, as reported by Nagata et al., in 1999.3WARNING This product is not for human or veterinary use.
