Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol.
1 It inhibits rat liver mitochondrial and
E. coli protein synthesis by 90.6 and 98.8%, respectively, when used at a concentration of 93 μM, and inhibits DNA synthesis in human lymphoblastoid cells by 83% at 1 mM. Bromamphenicol can also bind to the major adhesin subunit DraE from
E. coli.
2
