Bafetinib

$19 - $6125

Product nameBafetinib
Cas No859212-16-1
MFC30H31F3N8O
MW576.62
MDL NumberMFCD18633200

Synonyms

Benzamide, N-(3-((4,5'-bipyrimidin)-2-ylamino)-4-methylphenyl)-4-(((3S)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-3-(trifluoromethyl)-;Inno 406;Inno-406;4-[[(3S)-3-Dimethylaminopyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide;Ns 187;Unii-nvw4Z03I9b;Bafetinib (INNO-406);N-[3-([4,5'-BipyriMidin]-2-ylaMino)-4-Methylphenyl]-4-[[(3S)-3-(diMethylaMino)-1-pyrrolidinyl]Methyl]-3-(trifluoroMethyl)benzaMide

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Price

62 prices

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aablocks Ambeed Cayman Chemical ApexBio Technology Arctom TRC Axon Medchem ChemScene Adipogen Life Sciences AK Scientific DC Chemicals ACHEMBLOCK Biosynth AvaChem Usbiological Biorbyt Ltd American Custom Chemicals Corporation Labseeker
Package less more

10mm*1mlindmso 25mg 50mg 100mg 200mg 250mg 1g 1mg 1ml(10mmindmso) 5mg 10mg 10mm*1mlindmso(solution) 2mg 10mm*1mlindmso(solid+solvent)

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Brand	Packaging	Price	Product name
aablocks AA00GTUD	1mg	$19	Bafetinib
aablocks AA00GTUD	5mg	$62	Bafetinib
aablocks AA00GTUD	10mg	$104	Bafetinib
aablocks AA00GTUD	25mg	$150	Bafetinib
aablocks AA00GTUD	50mg	$179	Bafetinib
aablocks AA00GTUD	100mg	$316	Bafetinib
aablocks AA00GTUD	200mg	$404	Bafetinib
ACHEMBLOCK M22584	100MG	$440	Bafetinib
ACHEMBLOCK M22584	25MG	$190	Bafetinib
Adipogen Life Sciences SYN-1179-M005	5mg	$184	Bafetinib

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Properties

Melting point	166-168°C
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	DMSO:42.0(Max Conc. mg/mL);72.84(Max Conc. mM)
form	A crystalline solid
pka	12.72±0.70(Predicted)
color	Light yellow to yellow

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H303：May be harmfulif swallowed

H320：Causes eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312：Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib , with modifications added to improve binding and potency against Bcr-Abl kinase (IC50 = 5.8 nM). It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo. Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC50 = 19 nM), which has been associated with resistance to imatinib in CML.

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Suppliers and manufacturers

career henan chemical co

$1.00

Bafetinib

CAS:859212-16-1
TargetMol Chemicals Inc.

$31.00

Bafetinib

CAS:859212-16-1
Dideu Industries Group Limited

$1.10

Bafetinib USP/EP/BP

CAS:859212-16-1
Xiamen AmoyChem Co., Ltd
CONIER CHEM AND PHARMA LIMITED
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
TargetMol Chemicals Inc.
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
Zibo Hangyu Biotechnology Development Co., Ltd

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