AT-56

$15 - $2395.3

Product nameAT-56
Cas No162640-98-4
MFC25H27N5
MW397.52
EINECS200-256-5
MDL NumberMFCD18086874

Synonyms

AT56/AT-56;4-(DIBENZO[1,2-A:1',2'-E][7]ANNULEN-11-YLIDENE)-1-[4-(2H-TETRAZOL-5-YL)BUTYL]PIPERIDINE;4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(1H-tetrazol-5-yl)butyl]piperidine;4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine;AT 56;4-Dibenzo[a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine;AT 56, >=98%;CS-1414

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Price

48 prices

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aablocks Cayman Chemical ChemScene ACHEMBLOCK Sigma-Aldrich Arctom CSNpharm TRC AK Scientific American Custom Chemicals Corporation Tocris Crysdot DC Chemicals ApexBio Technology Usbiological Chemenu Medical Isotopes, Inc. Biorbyt Ltd Biosynth
Package less more

10mm*1mlindmso 10 50 1mg 5mg 10mg 25mg 50mg 100mg 250mg 1000mg 1g

Clear All Done

Brand	Packaging	Price	Product name
aablocks AA001T7C	25mg	$55	AT-56
aablocks AA001T7C	50mg	$93	AT-56
aablocks AA001T7C	5mg	$15	AT-56
aablocks AA001T7C	100mg	$158	AT-56
ACHEMBLOCK R16072	100MG	$295	AT-56
ACHEMBLOCK R16072	25MG	$110	AT-56
AK Scientific 0268CT	1mg	$139	CID11741525
American Custom Chemicals Corporation KIN0001044	1MG	$145.95	4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-(4-(2H-TETRAZOL-5-YL)BUTYL)-PIPERIDINE
American Custom Chemicals Corporation KIN0001044	5MG	$500.06	4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-(4-(2H-TETRAZOL-5-YL)BUTYL)-PIPERIDINE
ApexBio Technology B5445	10mg	$314	AT 56

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Properties

Boiling point	620.4±65.0 °C(Predicted)
Density	1.216±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: soluble10mg/mL, clear
pka	4.99±0.10(Predicted)
form	powder
color	white to beige
InChI	1S/C25H27N5/c1-3-9-22-19(7-1)12-13-20-8-2-4-10-23(20)25(22)21-14-17-30(18-15-21)16-6-5-11-24-26-28-29-27-24/h1-4,7-10,12-13H,5-6,11,14-18H2,(H,26,27,28,29)
InChIKey	LQNGMDUIRLSESZ-UHFFFAOYSA-N
SMILES	N1(CCCCC2=NNN=N2)CC/C(=C2/C3=CC=CC=C3C=CC3=CC=CC=C3/2)/CC1

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H228：Flammable solid

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P210：Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240：Ground/bond container and receiving equipment.

P241：Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

P370+P378：In case of fire: Use … for extinction.

Description

Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin-type enzyme (β-trace, L-PGDS) and the hematopoietic-type enzyme (H-PGDS). L-PGDS is localized in the central nervous system, male genital organs of various mammals, and the human heart and is a major protein in human cerebrospinal fluid (CSF). AT-56 is a selective, competitive, and highly bioavailable inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) with a Ki value of 75 μM. It inhibits the production of PGD2 by L-PGDS-expressing cells purified from human CSF and recombinant mouse cells with an IC50 value of 95 μM. At concentrations as high as 100 μM in vitro or 30 mg/kg in vivo, AT-56 does not affect the production of PGE2, PGF2α, or H-PGDS-catalyzed PGD2. At 10 mg/kg AT-56, the numbers of total cells, infiltrating eosinophils, and monocytes in bronchoalveolar lavage fluid of L-PGDS transgenic mice were decreased to 23, 6, and 41% of controls, respectively.

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Suppliers and manufacturers

career henan chemical co

$5.00

4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine

CAS:162640-98-4
TargetMol Chemicals Inc.

$33.00

AT-56

CAS:162640-98-4
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
Zibo Hangyu Biotechnology Development Co., Ltd
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