AT-56

$37 - $2395.3

Product nameAT-56
Cas No162640-98-4
MFC25H27N5
MW397.52
EINECS200-256-5
MDL NumberMFCD18086874

Synonyms

AT56/AT-56;4-(DIBENZO[1,2-A:1',2'-E][7]ANNULEN-11-YLIDENE)-1-[4-(2H-TETRAZOL-5-YL)BUTYL]PIPERIDINE;4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(1H-tetrazol-5-yl)butyl]piperidine;4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine;AT 56;4-Dibenzo[a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine;AT 56, >=98%;CS-1414

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Price

29 prices

Brand less more

Sigma-Aldrich Cayman Chemical CSNpharm Crysdot Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology AK Scientific Medical Isotopes, Inc. ChemScene American Custom Chemicals Corporation DC Chemicals
Package less more

50 1mg 5mg 10mg 25mg 50mg 10 100mg 250mg 1g 1000mg

Clear All Done

Brand	Packaging	Price	Product name
AK Scientific 0268CT	1mg	$139	CID11741525
American Custom Chemicals Corporation KIN0001044	1MG	$145.95	4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-(4-(2H-TETRAZOL-5-YL)BUTYL)-PIPERIDINE
American Custom Chemicals Corporation KIN0001044	5MG	$500.06	4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-(4-(2H-TETRAZOL-5-YL)BUTYL)-PIPERIDINE
ApexBio Technology B5445	50mg	$1127	AT56
ApexBio Technology B5445	10mg	$266	AT56
Biorbyt Ltd orb181201	250mg	$1504.5	AT-56
Biorbyt Ltd orb181201	1000mg	$2395.3	AT-56
Biorbyt Ltd orb181201	100mg	$838.1	AT-56
Cayman Chemical 13160	50mg	$704	AT-56
Cayman Chemical 13160	10mg	$161	AT-56

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Properties

Boiling point	620.4±65.0 °C(Predicted)
Density	1.216±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: soluble10mg/mL, clear
pka	4.99±0.10(Predicted)
form	powder
color	white to beige
InChIKey	LQNGMDUIRLSESZ-UHFFFAOYSA-N
SMILES	N1(CCCCC2=NNN=N2)CC/C(=C2/C3=CC=CC=C3C=CC3=CC=CC=C3/2)/CC1

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H228：Flammable solid

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P210：Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240：Ground/bond container and receiving equipment.

P241：Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

P370+P378：In case of fire: Use … for extinction.

Description

Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin-type enzyme (β-trace, L-PGDS) and the hematopoietic-type enzyme (H-PGDS). L-PGDS is localized in the central nervous system, male genital organs of various mammals, and the human heart and is a major protein in human cerebrospinal fluid (CSF). AT-56 is a selective, competitive, and highly bioavailable inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) with a Ki value of 75 μM. It inhibits the production of PGD2 by L-PGDS-expressing cells purified from human CSF and recombinant mouse cells with an IC50 value of 95 μM. At concentrations as high as 100 μM in vitro or 30 mg/kg in vivo, AT-56 does not affect the production of PGE2, PGF2α, or H-PGDS-catalyzed PGD2. At 10 mg/kg AT-56, the numbers of total cells, infiltrating eosinophils, and monocytes in bronchoalveolar lavage fluid of L-PGDS transgenic mice were decreased to 23, 6, and 41% of controls, respectively.

Suppliers and manufacturers

career henan chemical co

$5.00/5KG

4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine

CAS:162640-98-4
TargetMol Chemicals Inc.

$33.00/1mg

AT-56

CAS:162640-98-4
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
ATK CHEMICAL COMPANY LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
Hangzhou MolCore BioPharmatech Co.,Ltd.
Nantong HI-FUTURE Biology Co., Ltd.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd

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