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ChemicalBook > CAS DataBase List > N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

  • $25 - $2025.29
  • Product name:N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
  • CAS:902135-91-5
  • MF: C16H18Cl3N5O2
  • MW:418.7
  • EINECS:
  • MDL Number:MFCD14636428
  • Synonyms:N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl;AT7519;AT-7519;AT 7519 HYDROCHLORIDE;AT-7519 HYDROCHLORIDE;4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl;CS-266;AT7519; AT-7519;AT 7519;N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride;AT7519 (Hydrochloride)
Price
  • Brand:DC Chemicals
  • Product number:DC1025
  • Product nameAT7519HCL
  • Purity:99%
  • Packaging:1 g
  • Price:$1200
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:DC Chemicals
  • Product number:DC1025
  • Product nameAT7519HCL
  • Purity:99%
  • Packaging:250 mg
  • Price:$600
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:DC Chemicals
  • Product number:DC1025
  • Product nameAT7519HCL
  • Purity:99%
  • Packaging:100 mg
  • Price:$300
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:TRC
  • Product number:D432100
  • Product name4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylicAcidPiperidin-4-ylamideMonohydrochloride
  • Purity:
  • Packaging:5mg
  • Price:$165
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:TRC
  • Product number:D432100
  • Product name4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylicAcidPiperidin-4-ylamideMonohydrochloride
  • Purity:
  • Packaging:50mg
  • Price:$1320
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
Safety Information
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Description

AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.


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