LY303511 is a close structural analog of LY294002 , a selective phosphatidylinositol 3-kinase (PI3K) inhibitor.
1 LY303511, however, does not inhibit PI3K-dependent phosphorylation of Akt but instead has been shown to inhibit mTOR-dependent phosphorylation of S6K.
1 It can reduce cell proliferation in human lung epithelial adenocarcinoma cells, blocking G
2/M progression and inhibiting casein kinase 2 activity.
1 LY303511 demonstrates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity in HeLa cells that are refractory to TRAIL-induced apoptosis.
2 LY303511 is also reported to block voltage-gated potassium (K
v) channels.
3
