(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide;CHIC-35;Compound (S)-35;SIRT1 Inhibitor IV, (S)-35;(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide;SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem;Cyclohept[b]indole-6-carboxamide, 2-chloro-5,6,7,8,9,10-hexahydro-, (6S)-
P301+P310：IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
SIRT 1 inhibitor IV, (S)-35 is a highly potent inhibitor of SIRT1 (IC50 = 38 nM). It is an entomerically pure compound that can permeate the cell and is metabolically stable. The inhibitor is similar in structure, potency (IC50 = 63 nM), and selectivity to SIRT1 inhibitor III. Sirt4-7 and class I/II HDAC are not inhibited by SIRT1 inhibitor (concentrations up to 100μM). Data shows that inhibition of SIRT1 by SIRT1 Inhibitor IV, (S)-35 enhances acetylation of p53 in response to DNA damaging agents.
![(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide](https://www.chemicalbook.com/CAS/20150408/GIF/848193-72-6.gif)
