3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-]

Destruxin B₂ is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities. It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC₅₀ = 1.3 μM). Destruxin B₂ is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS₅₀) value of 92 μM. It is also phytotoxic to B. napus leaves.