4-Chloro-2-cyclopropyl-6-methylpyrimidine is a useful research chemical compound used as a reactant in the preparation of N-(4-arylpiperazinoalkyl)pyrimidine-4-carboxamides targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant.