4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine ;BW-755C;CGS-13592;2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine;3-amino-1-<3-(trifluoromethyl)phenyl>-2-pyrazoline;1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-;1-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine;BW 755C, 10 mM in DMSO
≤30mg/ml in ethanol;30mg/ml in DMSO;25mg/ml in dimethyl formamide
form
crystalline solid
pka
2.57±0.70(Predicted)
color
Brown to reddish brown
Description
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways, inhibiting 5-LO, COX-1, and COX-2 (IC50s = 0.75 μM, 0.65 μg/ml, and 1.2 μg/ml, respectively). It may also inhibit other LO pathways in vivo. Through these actions, BW 755C diminishes inflammation.
![4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine](https://www.chemicalbook.com/CAS/GIF/66000-40-6.gif)
