MIM1;4-[[[2-(Cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol;1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-;MIM 1;MIM-1;CS-1192;Inhibitor of Mcl-1;1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-;inhibit,Bcl-2 Family,Inhibitor of Mcl1,Inhibitor,MIM-1,MIM1,MIM 1,Inhibitor of Mcl 1
insoluble in EtOH; insoluble in H2O; ≥12.15 mg/mL in DMSO
form
A crystalline solid
pka
7.73±0.45(Predicted)
color
White to off-white
Description
MIM1 is an inhibitor of Mcl-1, an antiapoptotic Bcl-2 family protein with a role in cancer. It selectively engages the canonical groove of Mcl-1, inhibiting its ability to bind BH3 domains (IC50 = 4.7 μM). MIM1 induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells.
