N-Sulfinyltritylamine, TrNSO, is a stable linchpin reagent for the one-pot synthesis of diverse sulfonimidamides. Reported by the laboratory of Michael Willis, TrNSO can be used to join organometallic reagents and amines to assemble differentially substituted sulfonimidamides in high yields. TrNSO will find utility in medicinal and agrochemistry applications where more efficient synthetic methods are required for this increasingly significant functional group.
