P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
Acetylthiomethyl-diphenylphosphine borane complex is a traceless Staudinger ligation reagent with borane protecting group. The borane group works to stabilize the phosphine against oxidation and then it can be easily removed with mild basic or acidic conditions to yield the active phosphine. After reaction with an azide, the phosphine is eliminated in the presence of water to yield a native amide bond. It is used in the synthesis of cyclic peptides.