Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors -
LPA
1/EDG-
2, LPA
2/EDG-
4, LPA
3/EDG-
7 and LPA
4/GPR23.
1,2 OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA
3) receptor. It exhibits EC
50 values of 68 nM and >6.8 μM for calcium mobilization in LPA
1 and LPA
2-
expressing Sf9 cells, respectively.
3 The (2S)-
OMPT enantiomer is 5-
to 20-
fold more active than (2R)-
OMPT in calcium release assays in both LPA
3-
transfected Sf9 and rat hepatoma Rh7777 cells.
4
