N-Arachidonoyl-L-serine-d8 is an isotopic analogue of N-Arachidonoyl-L-serine (A765110), which is a novel neuroprotective endocannabinoid with weak affinity for CB1 and CB2 cannabinoid receptors. It is also a pro-angiogenic factor and a vessel dilator. Shows proneurogenic properties in vitro and in vivo in mice model of traumatic brain injury.