Carbonic Anhydrase IX/XII Inhibitor II(U-104)

$11 - $2491

Product nameCarbonic Anhydrase IX/XII Inhibitor II(U-104)
Cas No178606-66-1
MFC13H12FN3O3S
MW309.32
MDL NumberMFCD00159265

Synonyms

NSC 213841;Carbonic Anhydrase IX/XII Inhibitor II(U-104);MST-104 ;4-[[[(4-Fluorophenyl)amino]carbonyl]amino]benzenesulfonamide;U104/NSC 213841/MST104;U-104;NSC 213841;U 104;4-[[[(4-Fluorophenyl)aMino]carbonyl]aMino]-benzenesulfonaMide, NSC 213841;Benzenesulfonamide, 4-[[[(4-fluorophenyl)amino]carbonyl]amino]-

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Price

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aablocks ChemScene Cayman Chemical ApexBio Technology CSNpharm Matrix Scientific Ambeed Sigma-Aldrich TRC Tocris AK Scientific DC Chemicals American Custom Chemicals Corporation TCI Chemical ACHEMBLOCK Crysdot Biorbyt Ltd Usbiological
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10mm*1mlindmso 10μg 1mg 5mg 10mg 25mg 50 50mg 50.00mg 100.00mg 100mg 10mm(in1mldmso) 500mg 1g 5g 100μl 250.00mg 250mg 10 25μl

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Brand	Packaging	Price	Product name
aablocks AA00ABMJ	1mg	$11	U-104
aablocks AA00ABMJ	5mg	$19	U-104
aablocks AA00ABMJ	10mg	$24	U-104
aablocks AA00ABMJ	50mg	$61	U-104
aablocks AA00ABMJ	100mg	$94	U-104
aablocks AA00ABMJ	250mg	$158	U-104
ACHEMBLOCK O33724	250MG	$245	U-104
ACHEMBLOCK O33724	1G	$610	U-104
ACHEMBLOCK O33724	5G	$1920	U-104
AK Scientific X5935	25mg	$211	U-104

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Properties

Melting point	242-243℃
Density	1.523±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	2-8°C
solubility	DMSO: >15mg/mL
form	powder
pka	9.94±0.12(Predicted)
color	white to beige
biological source	rabbit
InChIKey	YJQZNWPYLCNRLP-UHFFFAOYSA-N
SMILES	Fc1ccc(cc1)NC(=O)Nc2ccc(cc2)[S](=O)(=O)N

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H320：Causes eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Carbonic anhydrases are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to form bicarbonate ion plus a proton. Carbonic anhydrases IX (CAIX) and CAXII are hypoxia and HIF-1-inducible proteins located in cellular transmembranes that regulate intra- and extracellular pH under hypoxic conditions and promote tumor cell survival and invasion in hypoxic microenvironments. U-104 is a ureido-sulfonamide inhibitor of transmembrane CAIX (Ki = 45.1 nM) and CAXII (Ki = 4.5 nM). It demonstrates reduced affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 μM, respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.

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Suppliers and manufacturers

career henan chemical co

$1.00

Carbonic Anhydrase IX/XII Inhibitor II(U-104)

CAS:178606-66-1
TargetMol Chemicals Inc.

$30.00

U-104

CAS:178606-66-1
ATK CHEMICAL COMPANY LIMITED
Alchem Pharmtech,Inc.
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem

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