C8 D-
threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.
1 It is cytotoxic to U937 cells (IC
50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide .
1,2 C8 D-
threo Ceramide is a substrate for
E. coli diacylglycerol kinase.
1 It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-
threo Ceramide also enhances
V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD
50) value of ~5 μg/ml.
3
