?ARN14974 is a benzoxazolone carboxamide that potently inhibits acid ceramidase (IC50 = 79 nM). This effect is persistent, as it inhibits acid ceramidase activity in cells for up to 24 hours. ?ARN14974 is extremely stable in buffers and plasma and shows good pharmacokinetics when administered intravenously or intraperitoneally in mice. It causes a significant reduction in acid ceramidase activity in multiple organs in mice, including brain, liver, heart, lungs, and kidney.
