PAMAM dendrimer, generation 6 solution 5 wt. % in methanol

PAMAM dendrimer G6.0 amine (PAMAM G6.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vivo.1 It is approximately 67 Å in diameter and has 256 surface groups.2 PAMAM G6.0 is active against clinical isolates of several bacteria (MICs = 0.25-25 µg/ml).3 It increases the cell growth rate of HEK293T and HeLa cells when used at concentrations ranging from 100 to 500 nM but is cytotoxic to the same cells when used at concentrations greater than or equal to 700 nM.4 PAMAM G6.0 in complex with the phosphodiesterase 5 (PDE5) and PDE6 inhibitor vardenafil (Item No. 14930) increases the oral bioavailability of vardenafil in rabbits.1 It has been used to deliver MRI contrast agents in mice.5WARNING This product is not for human or veterinary use.