D-myo-Inositol-1,4,5,6-tetraphosphate, sodium salt is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)P4 by intestinal epithelial cells increases approximately 2-14 fold, following infection with Salmonella. Ins(1,4,5,6)P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins(1,4,5,6)P3 is less potent than Ins(1,4,5)P3 at initiating Ca2+ release when injected into Xenopus oocytes.
