[1-(6-hydroxyhexyl)indol-3-yl]-naphthalen-1-ylmethanone

Cannabimimetic indoles, including certain JWH compounds, have been identified in herbal blends. JWH 018, a potent agonist of both the central cannabinoid (CB₁) receptor and peripheral cannabinoid (CB₂) receptor, has been found in many herbal blends and has been regulated in the United States and other countries. Studies indicate that JWH 018 is rapidly metabolized by the liver and that certain metabolites can be identified in the urine.^1,2,3 JWH 019 is nearly identical to JWH 018 in structure and activity at both CB receptors.⁴ JWH 019 N-(6-hydroxyhexyl) metabolite is an expected metabolite of JWH 019, detectable both in serum and urine. Its biological activities have not been evaluated.