Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-

The serine hydrolase known as α/β-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (2-AG; ) to regulate its availability at cannabinoid receptors. KT195 is a selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ. While it can be used as a probe to study ABHD6, it also has use as a negative control for studies of DAGLβ. By inactivating ABHD6, KT195 has been shown to induce a significant accumulation of 2-AG in Neuro2a cells. KT195 is also reported to reduce IL-1β secretion from lipopolysaccharide-treated macrophages.