JWH 018 is a synthetic cannabinoid (CB) that potently activates both the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively). This cannabimimetic compound has frequently been found in herbal blends. Structurally, JWH 018 is an alkylindole joined to a naphthyl group by methanone. JWH 018 8-quinolinyl carboxamide is a structural analog of JWH 018 in which the naphthalenyl methanone portion has been replaced by 8-quinolinyl carboxamide. The physiological and toxicological properties of this compound have not been investigated. This product is intended for research and forensic applications.
