JWH 081 8-methoxynaphthyl isomer

JWH 081 is a synthetic cannabinoid (CB) that shows a high-affinity for the central CB₁ receptor with a K_i value of 1.2 nM and ten-fold reduced affinity for the peripheral CB₂ receptor (K_i = 12.4 nM). JWH 081 8-methoxynaphthyl isomer differs structurally from JWH 081 by having the methoxy group attached to the naphthyl rings at the 8 position, instead of the 4 position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.