JWH 018 N-pentanoic acid metabolite-d4

JWH 018 N-pentanoic acid metabolite-d₄ contains four deuterium atoms at the 3, 3’, 4, and 4’ positions. It is intended for use as an internal standard for the quantification of JWH 018 N-pentanoic acid metabolite by GC- or LC-mass spectrometry (MS). JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB₂) receptor, derived from the aminoalkylindole WIN 55,212-2. The K_i values for binding central cannabinoid (CB₁) and CB₂ receptors are 9.0 and 2.94 nM, respectively, for a CB₁:CB₂ ratio of 3.06. JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. JWH 018 N-pentanoic acid metabolite is a minor urinary metabolite of JWH 018, characterized by carboxylation of the N-alkyl chain. In urine samples, this metabolite is almost completely glucuronidated.