(±)12(13)-EpOME-d4 is intended for use as an internal standard for the quantification of 12(13)-EpOME by GC- or LC-MS. 12(13)-EpOME is an epoxide formed primarily via metabolism of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) by the cytochrome P450 (CYP) isoforms CYP2J2, CYP2C8, and CYP2C9, however, CYP1A1 can contribute to 12(13)-EpOME production when pharmacologically induced.1 12(S),13(R)-EpOME and 12(R),13(S)-EpOME are produced at equal proportions from linoleic acid by peroxygenase, whereas CYP450-mediated metabolism of linoleic acid exclusively produces 12(S),13(R)-EpOME, in E. lagascae microsomes.2WARNING This product is not for human or veterinary use.
