JAK2 Inhibitor III, SD-1029 is a cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. Has been shown to display a lower effect on the cellular phosphorylation levels of Jak1 and Src and shows little inhibition towards a panel of 49 other protein kinases in cell-free kinase assays. JAK2 Inhibitor III, SD-1029 has been shown to effectively inhibit cell proliferation in JAK-activated BA/F3 cell lines as well as phosphorylation and nuclear translocation of cellular Stat3.
