(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide

2-Arachidonyl glycerol (2-AG) exhibits cannabinoid agonist activity at the central cannabinoid (CB₁) receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB₁ receptor^1,2. 2-AG can also be metabolized by COX-2 to form prostaglandin (PG) 2-glyceryl esters.³ These 2-glyceryl esters rapidly equilibrate to form 90:10 mixtures favoring the more stable 1-glyceryl ester. 17-phenyl trinor PGF_2α serinol amide is a stable analog of PGF_2α 2-glyceryl ester incorporating an activity-enhancing 17-phenyl substitution. The biological activity of 17-phenyl trinor PGF_2α serinol amide has not yet been determined.