P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…
Description
The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers. PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of human adrenocortical cell lines with PNU 74654 significantly reduced expression of several Tcf/β-catenin target genes.