Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
Symbol(GHS)
Signal word
Warning
Hazard statements
H302：Harmful if swallowed
Precautionary statements
P264：Wash hands thoroughly after handling.
P264：Wash skin thouroughly after handling.
P270：Do not eat, drink or smoke when using this product.
P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501：Dispose of contents/container to..…
Description
The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers. PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of human adrenocortical cell lines with PNU 74654 significantly reduced expression of several Tcf/β-catenin target genes.
![2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide](https://www.chemicalbook.com/CAS/20181012/GIF/113906-27-7.gif)
