Cholecystokinin (CCK) is a peptide hormone that, through specific receptors, induces pancreatic growth and enzyme secretion, smooth muscle contraction in the gall bladder and stomach, and modulates feeding and behavior. Lorglumide is a nonpeptidic antagonist of the CCK A receptor (CCK1; IC50 = 50 nM) that is 60-fold less effective at the CCK B receptor (CCK2; IC50 = 3 μM). It blocks CCK-mediated gut muscle contraction, pancreatic growth, and pancreatic secretion. Lorglumide is commonly used to study the roles of CCK1 in tissues and in animals.
![(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM](https://www.chemicalbook.com/StructureFile/ChemBookStructure1/GIF/CB2176642.gif)
