1-
Octadecyl lysophosphatidic acid (1-
octadecyl LPA) is a LPA analog containing stearic acid at the
sn-
1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.
1,2 Alkyl ether-
linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-
specific LPA receptor. For example, 1-
octadecyl LPA has a platelet aggregating EC
50 value of 9 nM
versus 1-
octadecanoyl LPA which has an EC
50 value of 177 nM.
3
