Taltirelin suppliers

Taltirelin

CAS:: 103300-74-9

MF:: C17H23N7O5

MW:: 405.41

Use：: Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agonist of the TRH receptors that shows significant effects on the cerebral monoamine systems when administered i.p. in rats. As TRH at 10-fold higher doses, taltirelin has been found to increase the extracellular levels of dopamine and its metabolites (DOPAC and HVA) as well as precursors and/or metabolites of noradrenaline and serotonin in different areas of the rat brain. Taltirelin produced an anti-ataxic activity in the Rolling mouse Nagoya, an ataxic mutant mouse. In several clinical studies performed in patients suffering from various forms of SCD, taltirelin demonstrated a statistically significant increase in the global improvement of ataxic symptoms and other neurologic abnormalities.

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You can find Taltirelin suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Sigma Audley

Taltirelin
Remarks: Purity: 99.9% | Package: 1box;25USD|20box;20USD|50box;15USD
TEL: +86-15937194204
CHINA Trader

Capot Chemical Co.,Ltd.

Taltirelin
Remarks: Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
TEL: 571-85586718
CHINA Trader

Shenzhen Nexconn Pharmatechs Ltd

Taltirelin hydrate
Remarks: Purity: 0.98 | Package: 1KG;10KG;50KG
TEL: +86-755-89396905
CHINA Trader

Shaanxi Pioneer Biotech Co., Ltd .

Taltirelin Acetate
Remarks: Purity: 0.99 | Package: 1g;25g;1kg;25kg;100kg
CHINA Trader

CONIER CHEM AND PHARMA LIMITED

taltirelin
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

career henan chemical co

Taltirelin
Remarks: Purity: 98% | Package: 1KG;1USD
TEL: 0371-86658258
CHINA Trader

￥1.00/1KG

SIMAGCHEM CORP

Taltirelin
Remarks: Purity: 0.99 | Package: 1kg,5kg,25kgs,200kgs;bulk
CHINA Trader

Dideu Industries Group Limited

Taltirelin
Remarks: Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
TEL: +86-29-89586680
CHINA Trader

Finetech Industry Limited

Taltirelin
Remarks: Purity: 98% | Package: 1g,10g,25g,100g,500g,1kg
TEL: +86-27-87465837
CHINA Trader

BOC Sciences

Taltirelin
Remarks: Purity: >98% | CustNote: BOC Sciences also provides custom synthesis services for Taltirelin.
TEL: 16314854226
UNITED STATES Reagent