Suramin sodium suppliers

Suramin sodium

CAS:: 129-46-4

MF:: C51H34N6Na6O23S6

MW:: 1429.17

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H317

Precautionary statements ：: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501

Safety Statements ：: 22-24/25

WGK Germany ：: 3

RTECS ：: QM7000000

F ：: 3-10

HS Code ：: 29242998

Toxicity：: LD50 in mice (mg/kg): ~620 i.v. (Hawking)

Use：: Suramin sodium is a high molecular-weight bisurea derivative containing six sulfonic acid groups as their sodium salts. It was developed in Germany shortly after World War I as a byproduct of research efforts directed toward the development of potential antiparasitic agents from dyestuffs. The drug has been used for more than half a century for the treatment of early cases of trypanosomiasis. Not until several decades later, however, was suramin discovered to be a long-term prophylactic agent whose effectiveness after a single intravenous injection is maintained for up to 3 months. The drug is tightly bound to plasma proteins, causing its excretion in the urine to be almost negligible. Tissue penetration of the drug does not occur, apparently because of its high molecular weight and highly ionic character. Thus, an injected dose remains in the plasma for a very long period. Newer, more effective drugs are now available for short-term treatment and prophylaxis of African sleeping sickness. Suramin is also used for prophylaxis of onchocerciasis. It is available from the CDC.

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You can find Suramin sodium suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

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