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ChemicalBook >> CAS DataBase List >>Methyldopa

Methyldopa suppliers

Methyldopa

CAS:: 555-30-6

MF:: C10H13NO4

MW:: 211.22

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H315-H319-H335

Precautionary statements ：: P261-P305+P351+P338

WGK Germany ：: 3

RTECS ：: YP2860000

F ：: 10-23

HS Code ：: 29181990

Hazardous Substances Data：: 555-30-6(Hazardous Substances Data)

Toxicity：: LD50 oral in rabbit: 713mg/kg

Use：: Methyldopa differs structurally from L-DOPA only in the presence of a -methyl group. Originally synthesized as an AADC inhibitor,methyldopa ultimately decreases the concentration of DA,NE, E, and serotonin in the CNS and periphery. However,its mechanism of action is not caused by its inhibition ofAADC but, rather, by its metabolism in the CNS to its activemetabolite ( β-methylnorepinephrine). Methyldopa istransported actively into CNS via an aromatic amino acidtransporter, where it is decarboxylated by AADC in thebrain to (1R,2S)- α-methyldopamine. This intermediate, inturn, is stereospecifically β-hydroxylated by DBH to givethe (1R,2S)-α-methylnorepinephrine. This active metaboliteis a selective α2-agonist because it has correct(1R,2S) configuration . It is currently postulated that α-methylnorepinephrine acts on α2-receptors in theCNS in the same manner as clonidine, to decrease sympatheticoutflow and lower blood pressure.

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