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Melphalan

148-82-3 Melphalan

CAS:: 148-82-3

MF:: C13H18Cl2N2O2

MW:: 305.2

SecurityInformation

Symbol(GHS) ：: GHS06,GHS08

Signal word ：: Danger

Hazard statements ：: H300-H317-H340-H350-H361

Precautionary statements ：: P201-P280-P301+P310+P330-P302+P352

Hazard Codes ：: T+

Risk Statements ：: 45-46-26/27/28-63-36/38-62

Safety Statements ：: 53-22-36/37/39-45

RIDADR ：: UN 2811 6.1/PG 2

WGK Germany ：: 3

RTECS ：: AY3675000

F ：: 8

HazardClass ：: 6.1(a)

PackingGroup ：: II

HS Code ：: 29224999

Toxicity：: LD50 i.p. in rats: 14.7 mmol/kg (Ross)

Use：: Melphalan is available in 2-mg tablets and 50-mg vials fororal and IV administration, respectively in the treatment ofmultiple myeloma, breast and ovarian cancer, and in highdosetherapy when bone marrow transplant is being utilized.The mechanisms of resistance are the same as those seen formechlorethamine. The agent is poorly absorbed when givenby the oral route. Melphalan is highly plasma protein bound(80%–90%) and inactivated in the blood by water to givethe hydroxy metabolites. Elimination occurs primarily in thefeces with an elimination half-life of 38 to 108 minutes. Thecommonly seen adverse effects are myelosuppression, nausea,and vomiting. Nausea is normally mild with normal doses butbecomes severe when high doses are used during bone marrowtransplant. Less commonly seen adverse effects are hypersensitivityreactions, skin rash, and alopecia. Secondarycancers are also of concern with the use of the agent.

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Sigma-Aldrich Co. LLC.

Sigma-Aldrich Co. LLC.

Melphalan
Remarks: Brand:Sigma-Aldrich | Product Number:M2011 | Purity:powder
TEL: 800 558-9160
UNITED STATES Trader

￥202.00/100MG

￥375.00/250MG

￥1070.00/1G

Cayman Chemical Company

Cayman Chemical Company

Melphalan
Remarks: Brand:Caymanchem | Product Number:16665 | Purity:≥95%
TEL: (800) 364-9897
UNITED STATES Trader

￥229.00/250mg

Tocris Bioscience

Tocris Bioscience

Melphalan
Remarks: Brand:Tocris Bioscience | Product Number:4619 | Purity:≥95%(HPLC)
TEL: +44 (0) 117 916 3333
UNITED KINGDOM Trader

￥104.00/50unit

1Pluschem LLC

1Pluschem LLC

Remarks: Brand:1pchem | Product Number:1P0039E5 | Purity:98%(HPLC)
TEL: (858)215-1656
UNITED STATES Trader

￥677.00/500mg

Medical Isotopes, Inc

Medical Isotopes, Inc

Melphalan
Remarks: Brand:medicalisotopes | Product Number:11504
TEL: （603）635-2255
UNITED STATES Reagent

￥1960.00/50mg

AHH Chemical Co,.Ltd

AHH Chemical Co,.Ltd

Melphalan
Remarks: Brand:ahhchemical | Product Number:API-1299 | Purity:97%
TEL: 86-1860259310
CHINA Trader

￥720.00/5g

Toronto Research Chemicals Inc.

Toronto Research Chemicals Inc.

Melphalan
Remarks: Brand:trc-canada | Product Number:M216900
TEL: +1 (416) 665-9696
CANADA Trader

￥70.00/5mg

￥245.00/25mg

￥465.00/50mg

￥880.00/100mg