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ChemicalBook >> CAS DataBase List >>Lomustine

Lomustine suppliers

Lomustine

CAS:: 13010-47-4

MF:: C9H16ClN3O2

MW:: 233.7

SecurityInformation

Symbol(GHS) ：: GHS06,GHS08

Signal word ：: Danger

Hazard statements ：: H301-H350

Precautionary statements ：: P201-P280-P301+P330+P331+P310-P308+P313

Hazard Codes ：: T

Risk Statements ：: 45-25

Safety Statements ：: 53-45

RIDADR ：: 3249

WGK Germany ：: 3

RTECS ：: YS4900000

HazardClass ：: 6.1(a)

PackingGroup ：: II

HS Code ：: 29299090

Toxicity：: LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson)

Use：: Lomustine is available in 10-, 40-, and 100-mg capsules fororal administration in the treatment of primary and metastaticbrain cancers and Hodgkin’s lymphoma. This lipophilicagent is well absorbed, widely distributed, and crosses theblood-brain barrier. Lomustine undergoes extensive hepaticmetabolism, which is mediated by CYP3A4 to give severalhydroxylated metabolites, which arise as a result of oxidationof the cyclohexyl ring. Several of these are more activethan the parent compound. Denitrosation and dechlorinationhave also been demonstrated to occur for lomustine as well.The intact drug was not found in plasma when the agent wasadministered orally. Elimination occurs primarily in theurine with an elimination half-life of 16 to 72 hours.Myelosuppression is dose limiting and presents in a mannersimilar to that seen with carmustine. Other toxicities includenausea, vomiting, anorexia, impotence, sterility, amenorrhea,and infertility. Pulmonary and renal toxicity are rarelyseen during standard-dose therapy but increase during highdosetherapy.

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You can find Lomustine suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Hebei Guanlang Biotechnology Co,.LTD

Lomustine
Remarks: Purity: 99.7%|Package: 1kg;2.70;USD
TEL: +86-19930503253
CHINA Trader

￥2.70/1kg

Shaanxi TNJONE Pharmaceutical Co., Ltd

Lomustine
Remarks: Purity: 99% | Package: 1kg
CHINA Trader

￥0.00/1kg

career henan chemical co

Lomustine
Remarks: Purity: 98% | Package: 1KG;1USD
TEL: 0371-86658258
CHINA Reagent

SHANDONG ZHI SHANG CHEMICAL CO.LTD

Lomustine
Remarks: Purity: 0.99 | Package: 1kg; 5kg; 25kg
TEL: 0531-68652808
CHINA Trader

Xiamen AmoyChem Co., Ltd

Lomustine
TEL: 592-+86-592-6051114
CHINA Service provider

Chongqing Chemdad Co., Ltd

Lomustine
Remarks: Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
TEL: 023-+86-023-61398051
CHINA Trader

CONIER CHEM AND PHARMA LIMITED

lomustine
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

TargetMol Chemicals Inc.

Lomustine；NSC 79037;CCNU
Remarks: Purity: 99.86% | Package: 1 mL * 10mM (in DMSO)；100 mg；200 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: 781-+1-781-999-5354
UNITED STATES Trader

Hefei TNJ Chemical Industry Co.,Ltd.

Lomustine
TEL: 0551-0551-65418671
CHINA Reagent

Dideu Industries Group Limited

Lomustine
Remarks: Purity: 99.9%|Package: 1g;1.1USD
TEL: 029-+86-29-89586680
CHINA Trader

￥1.10/1g