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ChemicalBook >> CAS DataBase List >>Docetaxel

Docetaxel suppliers

Docetaxel

CAS:: 114977-28-5

MF:: C43H53NO14

MW:: 807.88

SecurityInformation

Symbol(GHS) ：: GHS07,GHS08

Signal word ：: Danger

Hazard statements ：: H315-H319-H341-H360D-H362-H372

Precautionary statements ：: P202-P260-P263-P302+P352-P305+P351+P338-P308+P313

Hazard Codes ：: Xi

Risk Statements ：: 36/37/38-61

Safety Statements ：: 26-36/37-53-45

RIDADR ：: 1544

WGK Germany ：: 3

RTECS ：: DA4172750

HazardClass ：: 6.1(b)

PackingGroup ：: III

HS Code ：: 29322090

Toxicity：: LD50 intravenous in dog: 2500ug/kg

Use：: Docetaxel, a semi-synthetic product from the taxoid family, was launched in 1995 first in South Africa and subsequently in several other markets for the treatment of ovarian, breast and non-small cell lung cancers. Like the naturally occurring antitumor agent paclitaxel, the first marketed taxoid, docetaxel promotes both the rate and extent of tubulin assembly into stable microtubules and inhibits their depolymerization. It acts as a mitotic spindle poison and induces a mitotic block in proliferating cells. This mechanism of action for taxoids is unique from other classes of anticancer agents. Docetaxel was reported to be twice as potent as paclitaxel in several in vitro protocols and also exhibit higher cytotoxicity. Clinical trials are on going for docetaxel for other types of tumors including pancreatic, gastric, head and neck cancers and soft tissue sarcomas.

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You can find Docetaxel suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Taizhou Creating Bio-pharm co., ltd.